RNase_PH: 3' exoribonuclease family, domain 1
| PAG Title | RNase_PH: 3' exoribonuclease family, domain 1 |
| PAG ID | PEX002507 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | This family includes 3-5 exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3-5 direction. The exosome is a 3-5 exoribonuclease complex that is required for 3 processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain 1. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 0 |
| Information Content | Poor |
| Other IDs | PF01138 |
| Base PAG ID | PEX002507 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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